To prevent acetone spills, always store acetone in sealed, acetone-resistant containers. Acetone dissolves most plastics except polypropylene. Keep containers in a cool, well-ventilated area away from heat to prevent pressure build-up.
Use secondary containment methods such as spill trays, especially when handling large amounts typical in acetone production settings. Regular inspections and strict handling protocols are essential, and staff should be trained on proper safety measures and spill response techniques.